業績・研究論文
業績・研究論文
原著論文
近年の当教室の研究成果をご紹介します。
2026年
- Otsu Y, Kawano T, Kajiwara S, Kikuchi J, Miyagi K, Orito K, Sakata K, Tanoue S, Hirohata M, Morioka M. Postoperative basal ganglia-dominant perfusion pattern predicts lower risk of transient neurological events after direct revascularization in moyamoya disease. AJNR Am J Neuroradiol 2026.〔血管障害〕
- Furuta K, Kikuchi J, Miyagi K, Orito K, Takasu O, Morioka M. Clinical significance of leakage sign patterns in acute subdural hematoma. J Neurotrauma 2026.〔外傷〕
- Sakata K, Negoto T, Hashimoto A, Sakai M, Kajiwara S, Nagata Y, Takahashi K, Morioka M. Simultaneous combined endonasal and transcranial surgery for large skull base tumors invading multiple regions. Neurosurg Rev 2026.〔腫瘍・頭蓋底〕
- Kajiwara S, Kikuchi J, Otsu Y, Sakata K, Ohkubo T, Furuta K, Kawano T, Hirohata M, Kaku Y, Mukasa A, Morioka M. Efficacy of occipital artery–encephaloduroarteriosynangiosis for posterior circulation ischemia in moyamoya disease. Oper Neurosurg 2026.〔血管障害〕
- Makizono T, Hasegawa Y, Kikuchi J, Hashimoto A, Furuta K, Koga M, Yoshitake H, Orito K, Morioka M. Impact of onset-to-imaging time on the predictive value of the leakage sign in supratentorial hemorrhage. Neurol Med Chir 2026.〔血管障害〕
- Yoshitake H, Negoto T, Moritsubo M, Furuta T, Jo M, Hirota T, Sakata K, Nakamura H, Morioka M. Chromosomal instability is associated with paradoxical cGAS upregulation and impaired STING signaling shaping the immune microenvironment in glioblastoma. Neuro-Oncology Advances 2026;vdag179.〔腫瘍・基礎〕
2025年
- Furuta T, Miyoshi H, Moritsubo M, Nakajima R, Negoto T, Nakamura H, Morioka M, Uchida Y, Ohtsuki S, Nakada M. Biological role and clinicopathological significance of leucine-rich α-2 glycoprotein 1 in the glioblastoma microenvironment. J Neuropathol Exp Neurol 2025;84(8):707–714.〔腫瘍・基礎〕
- Kikuchi J, Hasegawa Y, Kajiwara S, Otsu Y, Negoto T, Orito K, Takasu O, Hirohata M, Morioka M. Efficacy of step-down infusion method of a novel barbiturate therapy for severe subarachnoid hemorrhage with intracerebral hematoma. Neurol Med Chir 2025.〔血管障害〕
- Otsu Y, Kajiwara S, Kikuchi J, Negoto T, Orito K, Sakata K, Tanoue S, Hirohata M, Morioka M. Temporal base transdural anastomosis in moyamoya disease. Neurol Med Chir 2025.〔血管障害〕
- Kajiwara S, Hasegawa Y, Kikuchi J, Sakata K, Negoto T, Nakamura Y, Kawano T, Otsu Y, Kotaki Y, Nakamura H, Hirohata M, Morioka M. Prophylactic barbiturate step-down infusion therapy has similar and favorable effects in elderly and non-elderly patients with severe traumatic brain injuries. Brain Hemorrhages 2025.〔外傷〕
- Otsu Y, Yamakawa Y, Eto T, Yamashita S, Kuramoto T, Kawaguchi E, Hasegawa Y, Sakata K, Morioka M. Stereotactic evacuation performed during the subacute phase improves functional independence measurement scores in patients with putaminal hemorrhage. Cureus 2025.〔血管障害〕
- Kajiwara S, Hasegawa Y, Fujimori K, Morioka M. Step-down infusion of barbiturate improves neurofunction in a new rat model of rebleeding subarachnoid hemorrhage. Brain Hemorrhages 2025.〔血管障害・基礎〕
- Koga M, Hasegawa Y, Kikuchi J, Hashimoto A, Furuta K, Makizono T, Yoshitake H, Orito K, Morioka M. Leakage sign based on contrast-enhanced CT is a predictive marker for hematoma expansion and poor prognosis in primary brainstem hemorrhage. Brain Hemorrhages 2025.〔血管障害〕
- Kajiwara S, Kawano T, Hasegawa Y, Nakamura Y, Sakata K, Kikuchi J, Hirohata M, Morioka M. Impact of clazosentan on vasospasm reduction and functional recovery after aneurysmal subarachnoid hemorrhage. Neurol Med Chir 2025.〔血管障害〕
2024年
- Sugi K, Kikuchi J, Yoshitomi M, Orito K, Kajiwara S, Nakamura Y, Takeshige N, Takeuchi Y, Abe T, Morioka M. Leakage sign is a reliable predictor of hematoma expansion in acute epidural hematoma. World Neurosurg 2024.〔外傷〕
2023年
- Negoto T, Furuta T, Yoshitake H, Moritsubo M, Hashimoto A, Takeshige N, Sakata K, Nakamura H, Morioka M. Intratumoral thrombosis as a histological biomarker for predicting epidermal growth factor receptor alteration and poor prognosis in patients with glioblastomas. J Neurooncol 2023.〔腫瘍〕
- Sakata K, Komaki S, Takeshige N, Negoto T, Kikuchi J, Kajiwara S, Orito K, Nakamura H, Hirohata M, Morioka M. Visual outcomes and surgical approach selection focusing on active optic canal decompression and maximum safe resection for suprasellar meningiomas. Neurol Med Chir 2023.〔腫瘍・頭蓋底〕
- Kikuchi J, Arai H, Doi R, Takeuchi Y, Iwamoto R, Nishimura H, Morioka M. Preoperative novel magnetic resonance fusion imaging for carotid endarterectomy patients with contrast contraindications: a pilot study. World Neurosurg 2023.〔血管障害〕
- Otsu Y, Kajiwara S, Hashimoto A, Sakata K, Negoto T, Hasegawa Y, Nakamura H, Hirohata M, Morioka M. Effects of microvascular decompression on pain relief and quality of life in late elderly patients with trigeminal neuralgia. Neurol Med Chir 2023.〔機能的疾患〕
- Ohkubo T, Kajiwara S, Hasegawa Y, Hashimoto A, Takeuchi Y, Orito K, Kawano T, Fujimori K, Sakata K, Hirohata M, Morioka M. Bold-s signs on computed tomography angiography are sensitive markers for diagnosing subcortical hemorrhage due to dural arteriovenous fistulae on emergent admission. Neurol Med Chir 2023.〔血管障害〕
- Fujimori K, Kajiwara S, Hasegawa Y, Uchikawa H, Morioka M. Microscopic observation of morphological changes in cerebral arteries and veins in hyperacute phase after experimental subarachnoid hemorrhage: an in-vivo analysis. Neuroreport 2023.〔血管障害・基礎〕
2022年
- Miyahara T, Hattori G, Uchikado H, Kaku Y, Ohmori Y, Orito K, Takeuchi Y, Kawano T, Hirohata M, Mukasa A, Morioka M. Factors associated with rapidly deteriorating myelopathy in patients with spinal arteriovenous shunts. Neurol Med Chir 2022.〔脊髄〕
- Kikuchi J, Orito K, Sakata K, Yamamoto M, Hasegawa Y, Shojima T, Tayama E, Morioka M. Neurosurgical treatment of patients with posterior fossa acute subdural hematoma right after cardiac surgery. Neurol Med Chir 2022.〔外傷〕
- Orito K, Kajiwara S, Takeuchi Y, Sakata K, Abe T, Tanoue S, Uchiyama Y, Hirohata M, Morioka M. Relationship between transient cortical blindness and contrast medium leakage that occurs after endovascular treatment of posterior circulation aneurysms. J Neuroendovasc Ther 2022.〔血管障害〕
2021年
- Kotaki Y, Hattori G, Uchikado H, Komaki S, Takeshige N, Miyahara T, Hasegawa Y, Morioka M. "Motion-specific headache": a predictor for diagnosis and favorable prognosis after surgery in young patients with Chiari malformation type 1. Neurol Med Chir 2021.〔脊髄・頭蓋頚椎移行部〕
- Kajiwara S, Hasegawa Y, Negoto T, Orito K, Kawano T, Yoshitomi M, Sakata K, Takeshige N, Yamakawa Y, Jono H, Saito H, Hirayu N, Takasu O, Hirohata M, Morioka M. Efficacy of a novel prophylactic barbiturate therapy for severe traumatic brain injuries: step-down infusion of a barbiturate with normothermia. Neurol Med Chir 2021.〔外傷〕
- Sakata K, Nagata Y, Takeshige N, Kikuchi J, Shikata M, Ashida K, Nomura M, Morioka M. Early postoperative prediction of both disease remission and long-term disease control in acromegaly using the oral glucose tolerance test. Hormones (Athens) 2021.〔腫瘍・間脳下垂体〕
- Takeshige N, Uchikado H, Yoshitake H, Negoto T, Yoshitomi M, Sakata K, Morioka M. Long-term outcomes of endoscopic third ventriculostomy for Blake's pouch cyst in adults. Clin Neurol Neurosurg 2021.〔神経内視鏡〕
2020年
- Kikuchi K, Setoyama K, Takada S, Otsuka S, Nakanishi K, Norimatsu K, Tani A, Sakakima H, Kawahara K, Hosokawa K, Kiyama R, Sumizono M, Tancharoen S, Maruyama I, Hattori G, Morioka M, Tanaka E, Uchikado H. E8002 inhibits peripheral nerve adhesion by enhancing fibrinolysis of L-ascorbic acid in a rat sciatic nerve model. Int J Mol Sci 2020.〔脊髄・末梢神経・基礎〕
2019年
- Sakata K, Takeshige N, Nagata Y, Yoshitake H, Komaki S, Miyagi N, Morioka M. Endoscopic endonasal removal of primary/recurrent meningiomas in the medial optic canal: surgical technique and long-term visual outcome. Oper Neurosurg 2019.〔腫瘍・頭蓋底〕
- Takeshige N, Aoki T, Sakata K, Kajiwara S, Negoto T, Nagase S, Tanoue S, Uchiyama Y, Hirohata M, Abe T, Morioka M. Sagittal diffusion-weighted imaging in preventing the false-negative diagnosis of acute brainstem infarction. Surg Neurol Int 2019.〔血管障害〕
2018年
- Kikuchi K, Setoyama K, Terashi T, Sumizono M, Tancharoen S, Otsuka S, Takada S, Nakanishi K, Ueda K, Sakakima H, Kawahara K, Maruyama I, Hattori G, Morioka M, Tanaka E, Uchikado H. Application of a novel anti-adhesive membrane, E8002, in a rat laminectomy model. Int J Mol Sci 2018.〔脊髄・基礎〕
- Orito K, Hirohata M, Nakamura Y, Yamamoto M, Takeshige N, Aoki T, Hattori G, Sakata K, Takeuchi Y, Uzu H, Takasu O, Abe T, Uchiyama Y, Morioka M. Predictive value of leakage signs for pure brain contusional hematoma expansion. J Neurotrauma 2018.〔外傷〕
2016年
- Orito K, Hirohata M, Nakamura Y, Takeshige N, Aoki T, Hattori G, Sakata K, Abe T, Uchiyama Y, Sakamoto T, Morioka M. Leakage sign for primary intracerebral hemorrhage: a novel predictor of hematoma growth. Stroke 2016;47(4):958–963.〔血管障害〕
診療ガイドライン・総説
- Nakamura H, Takami H, Yanagisawa T, Kumabe T, Fujimaki T, Arakawa Y, et al.; The guideline committee in The Japan Society for Neuro-Oncology (JSNO) Task Force on Central Nervous System Germ Cell Tumors. The Japan Society for Neuro-Oncology guideline on the diagnosis and treatment of central nervous system germ cell tumors. Neuro-Oncology 2022;24(4):503–515.
- Takami H, Nakamura H, Ichimura K, Nishikawa R. Still divergent but on the way to convergence: clinical practice of CNS germ cell tumors in Europe and North America from the perspectives of the East. Neuro-Oncology Advances 2022;4(1):vdac061.
- Hoshino M, Sakata K, Kajiwara S, Mihashi R, Ohkubo T, Hashimoto A, Otsu Y, Ono T, Umeno H, Morioka M. Long-term efficacy of endoscopic endonasal transsphenoidal marsupialization using a nasoseptal mucosal flap for petrous apex cholesterol granuloma: systematic review and two case reports. Eur Arch Otorhinolaryngol 2026.
- Hasegawa Y, Uchikawa H, Kajiwara S, Morioka M. Central sympathetic nerve activation in subarachnoid hemorrhage. J Neurochem 2022;160(1).
- Uchikado H, Nishimura Y, Hattori G, Ohara Y. Micro-anatomical structures of the lumbar intervertebral foramen for full-endoscopic spine surgery: review of the literatures. J Spine Surg 2020.
- Tanoue S, Hirohata M, Takeuchi Y, Orito K, Kajiwara S, Abe T. Venous anatomy of the cavernous sinus and relevant veins. J Neuroendovasc Ther 2020.
- Sakata K, Fujimori K, Komaki S, Furuta T, Sugita Y, Ashida K, Nomura M, Morioka M. Pituitary gangliocytoma producing TSH and TRH: a review of "gangliocytomas of the sellar region". J Clin Endocrinol Metab 2020;105(10):3109–3121.